Since proteasomes are required for nuclear translocation of p65/NF-κB which in turn results in activation of NF-κB, it is worth substantial to consider proteasomes as the target of WA.
Thus, a small to moderate effect size might however, be substantial to the individual, especially considering that nearly daily headache i.e. mean 12/14 days reduced to mean 3/14 days [25], which equals ≥75% reduction in headache frequency.
Atoms, fundamental kinds of stuff, gods, or abstract entities, such as Platonic Forms or numbers, might be considered to be substantial to the point of being indestructible or eternal: they last at least as long as the world exists and, in the case of gods or God, or abstract entities, perhaps longer.
Some researchers have even suggested that the beneficial effects of helping others may be substantial enough to consider helping as possible adjunct to treatment for a disease [ 33].
One can, however, argue that the total redistributive effect from higher to lower income groups is substantial when considering the degree to which property taxes pay for schools and other services for low-income groups.
That is substantial considering that the United States has about 15,000 registered drug names.
Indeed, sequence divergence of the BoNT is substantial considering they share many similarities in a complex series of functions [24].
This difference in the median OS time is substantial, considering a median survival after liver resection of 27 months in our total study population.
Although some, like Benepe, consider this cost savings to be substantial, others consider it insignificant.
Performing the procedures in open stations may be regarded as a violation of independence of measurements, which, however, is unlikely to be substantial considering the study design features listed in the related section above.
