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There is substantial proof that getting the systolic pressure under 160 is beneficial, but the benefit of reducing it below 140 is unproven; we frankly don't know if that is helpful or harmful, or what blood pressure target is optimal.
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There still needs to be substantial proof that MOOC platforms offer a better learning experience (improve outcomes and retention rates), before higher ed simply turns over the keys to the kingdom.
If there were substantial proof, then maybe it's about time.
On Monday, Hellerstein said new Sony evidence offered "competent and substantial proof" that the cassette on which Arias allegedly recorded the song, which had been used to register a U.S. copyright, was not made in 1998 as claimed.
He and his staff have found substantial proof that Da Vinci's father owned a slave called Caterina.
But most of the world will certainly not accept an argument that Iraq had innocent technologies that it was planning to use later for deadly purposes, unless there is substantial supporting proof.
"That is substantial funding".
I'm proof that's not true.
They say that before many investors will make a substantial commitment to the market, they must see real proof that the economy and company earnings are indeed turning around.
This is the proof that it works".
Jokowi is the proof that democracy works.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com