In addition, the standard errors must be corrected using a Prais-Winsten estimation, as otherwise the models are subject to problems of specification.
However, recent studies have shown that low- and middle-latitude regions may also be subject to problems due to GIC occurrences.
When built on weak subgrades, these roads are subject to problems like excessive rutting and mud-pumping, increasing maintenance costs and usually leading to periodic interruptions to traffic.
Ecological studies are subject to problems of correlations between aggregated disease rates and aggregated measures of exposure which do not arise with studies which use individual data on disease, exposures and other risk factors.
Preload responsiveness parameters are not without their limitations: they require constant tidal volumes of around 7 to 8 ml/kg and sinus rhythm; they are subject to problems with damping of the arterial trace; and up until now they had limited validation in terms of improved clinical outcome.
Fundamentally, every existing sample of proteins is subject to these problems.
Extraction of RNA from biofluid samples is subject to technical problems not associated with extraction from tissues or cells.
Gene delivery through the transfection of plasmid DNAs or viral transductions inevitably imposes potential complications to gene alteration and is subject to safety problems.
> -wrap-foot> Our model of the impact of MHO membership on health care utilization is subject to possible problems of endogeneity and self-selection (Waters 1999).
Although highly active against most strains of C. difficile, rifaximin is subject to the problems of other rifamycins, whereby a critical amino acid substitution in the β-subunit of the bacterial RNA polymerase leads to high-level resistance [ 18, 19].
That plane is subject to a problem in bad weather called tailplane icing, in which the airplane's tail, which applies downward pressure at the back of the plane and holds the nose up, suddenly ceases to function.
