These miRNAs are speculated to regulate the expression of type I and type III collagens but also the laminin γ chain LAMC1.
A potential regulatory element at the 5'end of the IgH locus was speculated to regulate processes such as IgH allelic exclusion, VH germline transcription, differential accessibility or usage of distal versus proximal VH gene families.
The ability of BLU to regulate transcription is speculated to influence the level of proliferation regulators, and engagement of signaling pathways involving JNK and cyclin D1 may mechanistically elucidate the tumor suppressive role played by BLU.
In contrast, the rapid and transient induction of miR-9, miR-146a and miR-155 has been speculated to negatively regulate the acute responses following activation of innate immune through down-regulation of proteins involved in the receptor-induced signalling pathways.
Observations suggest these epimutations have a genomic feature of CpG deserts that are speculated to have significant roles in regulating genome activity [ 22].
Considering all these observations, it is speculated that curcumin regulates the expression of p53, which in turn modulates the expression of several miRNAs.
It is speculated that s1_contig11921 might regulate flowering in photoperiod pathway together with WNK8-like and EMF1-like in hickory.
It is speculated that TGF- β/Smad4 regulates expression of miR-155 resulting in down regulation of RhoA protein expression to drive EMT progression.
Downstream to the promoter region is the ACGT sequence that is required for etiolation induced expression of erd1 (early responsive to dehydration) gene in Arabidopsis (Simpson et al. 2003), hence it is speculated that OsHKT1 4 gene may regulate dehydration stress imposed by salinity.
Since systemic glucocorticoid levels are generally normal in patients with common forms of obesity or overweight type 2 diabetics,[ 21] it is speculated that the intracellular glucocorticoid concentration, regulated by 11β-HSDs, is responsible for the metabolic abnormalities.
