H. pylori containing the cagPAI have been speculated to decrease let-7 expression in the gastric epithelium via the pivotal mitogen-activated protein kinase and nuclear factor-κB (Roush and Slack, 2008; Peter, 2009; Matsushima et al, 2011).
This is speculated to be due to decreased circulating hormones, increased differentiation of the mammary cells and/or a decrease of mammary stem cells in the gland [ 7].
Thus, decreasing cadherin expression, and therefore few adherens junctions, is speculated to allow the uterus to expand to accommodate the growing embryo (Wu et al. 2011).
This has been speculated to be a cause of decreased efficacy of ASA therapy in diabetic patients [ 28].
This torsinAΔE mutant protein has been speculated to act in a dominant-negative manner to decrease activity of wild type torsinA.
This thin layer was speculated to be natural tungsten oxide.
Thus, it is speculated that the decreased Tregs and its ratio to Th17 and Th1 cells may display less immunosuppressive effect on monocytes/macrophages and likely drive these cells to an inflammatory state, which may contribute to the occurrence of complications.
It is speculated that by decreasing reservoir pressure, evolved gas would form noticeable gas saturation and flow as a bulk phase toward wellbore.
It is speculated that the decreased VEGF levels in COPD affect the pathogenesis of emphysema.
Since SSX1 is predicted to be a target for miR-143 in in silico databases such as miRBase or TargetScan, it is speculated that its decreased expression in synovial sarcoma enables the production of the SS18-SSX1 oncoprotein.
