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If the directionality of R5 or R8 is specified incorrectly, then alerting the user that D is a dead-end metabolite will help the user correct the directionality of R5 or R8, if appropriate.
Several reasons may cause this issue, including ri directly connecting to a dead-end metabolite or to another zero-flux reaction, or if the reversibility of the reaction is specified incorrectly.
Though the sandwich standard error estimator is consistent even when the underlying model is specified incorrectly, it tends to underestimate the standard error of the regression coefficient when the number of clusters is not large enough [ 21, 22].
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Another example is specifying incorrectly the coefficients of a particular reaction.
However, if these were specified incorrectly, the answer was considered wrong.
Another advantage is that even though the correlation model among the related outcome measures may be specified incorrectly, the association model between the outcome and covariates can still obtain a robust result.
No payment structure is specified.
No stipend was specified.
No amounts are specified.
No cause was specified.
That can all be specified.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com