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In order to reduce the possibility of either of these situations' occurring, this point is specifically stressed to the clinicians during their training sessions.
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But I was disappointed that at the very first press conference of the Dutch presidency, it was specifically stressed that unanimity would still be required on matters of fiscal policy.
In addition to the DNA damage checkpoint, cells are endowed with a DNA replication checkpoint that operates only during the S phase as it is specifically activated by stressed replication forks 82, 83.
Besides being involved in general checkpoint responses like inhibition of mitosis and activation of DNA repair mechanisms, the DNA replication checkpoint is specifically aimed at stabilizing stressed replication forks 92, 93.
Functional diversification of PSY was also found in rice and maize, where one of three PSYs is specifically involved in stress-induced ABA formation [18], [19].
It is unknown whether ALR is a constitutive process that participates in ongoing, steady-state proteostasis in vivo or whether it is a process that is specifically induced following stress-induced autophagy.
Those genes are not regulated by ER stress, and thus can be used to evaluate whether ER stress is specifically induced.
We found that alternative splicing of HBP/SLBP is specifically enhanced under replication stress and that notably it does not appear that replication stress conditions induced widespread changes to alternative splicing.
Whether IL-8 acts as a more general marker of stress or whether it is specifically involved in the physiological stress response of patients with RA is not yet clear.
However, our experiments illustrate that eIF2α is specifically phosphorylated when ER stress is induced (Figure 4D).
In addition, we have revealed the involvement of caspase-4, a protease that is specifically induced by ER stress in humans and may be involved in the pathogenesis of AD [18].
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