Human tissues are solely regulated under the PHS Act provided they meet certain criteria.
The 149 differentially regulated genes that were common between experiments I and II appear to be solely regulated by activated STATc.
In contrast, there are other genes which appear to be solely regulated by either CjFur (e.g. cfrA, chuA) or CjPerR (e.g. ahpC) [ 2, 4, 8].
We reasoned that if these single-repeat R3 MYB genes are solely regulated by these activator complexes, their expression would be dramatically reduced in gl3 egl3 double mutant due to the disruption of the activator complexes.
aMaximum absolute fold change determined by microarray analysis bDifferentially regulated genes with P1 t) > 0.9999 and |fold change| > 1.5 cTime point representing the maximum |fold change| Analysis of the C57BL/6 hepatic time course identified 552 unique genes that were solely regulated in vivo.
It has been suggested that expression of CYPs is not solely regulated at the level of gene transcription [ 11].
Although nontranscription functions could be caused by TF binding (mentioned above), this observation further supports the hypothesis that mtDNA transcriptional regulation is more complex than once assumed and that it is not solely regulated by mitochondria-dedicated factors.
Overall, these results suggest that the expression of CLDN3 and CLDN4 is not solely regulated by EZH2, or that H3K27me3 loss alone is insufficient to derepress their expression consistent with findings in previous reports (37, 38), and lend support to the idea that additional mechanisms might be involved in their regulation.
However, Dkk4 is a direct downstream target of Wnt [19], [20], [23], so that Dkk4 is not solely regulated by Eda.
