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"Chelsea is so substantive, and has two young children, that I don't see her playing White House social secretary.
This flaw, which is often discussed as a matter of tone, is so substantive that the Administration constantly undermines even its own best efforts.
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"I dare you to think of a summit that was so substantive".
On the day of the "Game of Thrones" premiere, Sunday July 16, 2017, the increase in revenue was so substantive that HBO NOW jumped up the top grossing chart by combined revenue by 11 ranks in the U.S., compared with the day prior.
Which is why it is so important now to have a substantive debate about both President Obama's vision of the federal government's role — and Paul Ryan's.
It is our hope that over the coming weeks and months your administration will use this tragic event to begin the process of, what Martin Luther King, Jr. called, "substantive equality," which is so desperately needed on this campus.
But by the end of the week, the reports of cheating were so numerous, and so substantive, that they could seriously undermine any claims to legitimacy by the eventual winner, whoever it is.
The prospect of being so close to making substantive strides in cardiac care, only to have budget politics get in the way, gnawed at him.
The curative effect of anti-HA antibody was so strong that a substantive recovery in memory performance tasks was observed.
The agency has been so reluctant to release any substantive details about the attack or the countermeasures it has taken since that Congress is calling for an independent investigation (PDF) by the Government Accountability Office.
Things are so good the presidential contenders are having a hard time finding substantive issues to debate.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com