Although O-GlcNAcylation of proteins integrates glucose metabolism with posttranslational modifications, this process is not simply regulated by substrate availability, as multiple stressors have also been shown to induce O-GlcNAcylation in cardiac tissue (47, 198, 199).
Thus, our findings suggest that TTP serves an entirely different role in other leukocytes, relative to their role in regulating cytokine production by macrophages, and that TNF production is not simply regulated by TTP.
These findings implicate that MYC expression in prostate cancer is not simply regulated by a gene dosage effect.
In some muscles, however, such as in the flight muscles of many insects, contraction is not simply regulated by the Ca2+ switch.
Furthermore, our findings demonstrate for the first time that B-Myb is not simply regulated by global phosphorylation at many sites but that distinct phosphorylation patterns exist that might have specific functions.
Therefore, there is a strong likelihood that genes that are regulated in the MYC signature may indeed have MYC bound at their promoters, but are simply not regulated and bound in ES cells.
To determine whether IL-12 cytokine family members were simply not regulated or selectively altered during protozoan infections, ex vivo recall responses to both parasites were performed.
According to this complex supramolecular organisation, GIRK channels are not simply regulated by G-protein subunits alone, but additional regulatory pathways mediated by phosphatitylinositole-4,5-bisphosphate, protein kinases and Na+ ions, also exist [1].
Moreover, the renal function, as indicated by eGFR did not affect the potassium dip, suggesting that the potassium kinetics during ischemic attack are not simply regulated by renal elimination.
Mind you, he said, a similar approach to the one taken in Colorado could work here, too: "We modelled it very close to alcohol, and obviously the UK is a big consumer of alcohol, so it's not like you need to start from scratch, right?" In Colorado the leading philosophy was simply named "Regulating Marijuana Like Alcohol".
