This mutation is significantly implicated in both sporadic and inherited human colorectal carcinogenesis [ 12- 14].
Retinal iron levels increase with age [ 1322], iron is significantly implicated in AMD [ 1323- 1329], and iron chelation may help to reverse the process [ 1330].
Finally, we note that NGAL is significantly implicated in pregnancy, and was even named uterocalin in mice to reflect its high expression in the uterus [ 361, 537- 539].
A case/control study investigating genetic variants of TNFRSF1A and 1B in association with the three main NOD2 variants, reported that one out of two SNPs from each gene was significantly implicated in the CD cohort [44].
Both TLR4 SNPs under investigation were found to be significantly implicated with HCV-infection among Saudi Arabian population.
The proposed technique predicted genes that are significantly implicated in cellular processes required for tissue regeneration after injury.
A general assertion is that for ACh to be significantly implicated in cognitive tasks, these tasks must be difficult and require effortful attention [ 11, 59].
It has been significantly implicated in the initiation and progression of glioblastoma (GBM), a very aggressive class of brain cancer [ 1- 3], where the median survival time of GBM patients is approximately 15 months [ 4].
This is reminiscent of the relevant SNPs of the DTNBP1 gene, which are mostly intronic and have been significantly implicated in the executive function of healthy controls [ 30], in cases belonging to early-onset families with functional psychosis disorders [ 65], and in the spatial working memory in patients with schizophrenia [ 66].
Nevertheless, the loss-of-function rare variants in the TREX1 and CYP27B1 genes have been significantly implicated in SLE and MS patients respectively (13, 14), suggesting the possibility that rare genetic variants may have a role in risk susceptibility for some of the less prevalent autoimmune diseases.
Loci that were most significantly implicated in these association studies are those mapping to or close to genes involved in neurotransmitter transport, biosynthesis and receptor activity, regulation of synaptic transmission, excitability and nervous system development, amino acid metabolism and chemotaxis.
