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Hypertonic stress is severely destructive for several proteins, including those of the contractile cell machinery, by causing their aggregation and misfolding in treated tissues and organs [ 41].
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104 Azathioprine, ciclosporin A or cyclophosphamide RA can run a course that is refractory to several DMARDs and biological agents and can be severely destructive and disabling.
It is severely eroded.
"She is severely burned.
Atan is severely malnourished.
He is severely malnourished.
Ahmed is severely mentally ill.
The programme is severely strained.
Infrastructure is severely damaged.
"One is severely injured.
He is severely autistic.
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