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S. pombe rad60 is required for response to DNA damaging agents and recovery from S phase arrest [28], [29], [30].
These data indicate that K14, and possibly K30, is required for response of cells to replication arrest.
Although ER expression is required for response to endocrine agents, ER-positive tumours may still fail to respond, e.g., due to cross talk with other pathways.
Answers to important questions for translational decisions, like where in the body SMN levels must be increased (both in neurons and peripherally) and when treatment is required for response (early intervention is better, but rescue is possible after onset of symptoms) have also been addressed.
Similar(56)
We conclude that whereas glutamate and neuropeptide signaling is required for responses to ΔT = 0.4°C, neuropeptides but not glutamate are dispensable for responses at ΔT = 1.0°C.
In S. cerevisiae, the HOG (High Osmolarity Glycerol) MAPK (Mitogen Activated Protein Kinase) pathway is required for responses to osmotic stress [ 4, 12].
Clearly, IGF-IR expression will be required for response to agents that target the IGF-IR.
Thus, although many molluscs show expansions of heat shock gene family members [ 51, 52], these may not all be required for response to thermal stress.
We suggest that cold-related cis-elements may be required for response to cold in roots outside the region contained in the B1S3 construct.
Interestingly, both NbSERK3 (Fig. 6) and CMPG1 are required for responses to INF1, when this protein is delivered by infiltration into the apoplast of N. benthamiana [7], [32].
Where statistical analysis was required for responses, IBM® SPSS® software was used.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com