Initiation and promotion together are required for causing cancer.
Despite the available of evidence on the influence of maternal education on child nutrition outcomes, it is not clear the threshold of maternal education that is required for cause a positive outcome on child nutritional status.
FoxO3 is required for and causes skeletal muscle atrophy through the ubiquitin-proteasome and autophagic-lysosomal proteolytic pathways [12], [13], [14], [47].
Reviewer 1: The study by Gomez et al. reports that knockout of Lrp4 in all tissues in mice except skeletal muscle (where it is required for survival), causes impairment in hippocampal-dependent learning and memory behavioral tasks, LTP at the Schaffer collateral, and a reduction in spine density in CA1 primary apical dendrites.
Thus, PPR signaling in T cells is required for cPTH to cause bone loss in male and female mice.
These findings suggest that NF-κB signaling is required for CNS disorders caused by C. neoformans and HIV-1 virulence factors.
Transcriptional adaptor 3 (TADA3L) is associated with and is required for full p53 activity, causing growth arrest, senescence, and p53-mediated apoptosis [56].
Nonadapted EBOV causes disease in nonhuman primates, but adaptation is required for the virus to cause disease in rodent models (1 – 4 ).
However, we found that Skn7 plays new roles in other cellular processes at low PKA activity: i) inhibits growth at 25 °C, ii) It is required for H2O2 resistance, iii) causes growth arrest in glucose at 36 °C, iv) causes growth arrest in acetate at 25 °C, v) causes growth arrest in galactose at 25 °C.
In a hypothetical case, as depicted in Figure 2, a concentration of more than 100 milligrams per gram in a target tissue is required for chemical A to cause toxic injury.
