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Collectively, these results suggest that Yap/Taz-Tead-dependent transcription is required autonomously within optic cup progenitor cells to generate RPE.
bib encodes a product with connexon channel activity, which is required autonomously in epidermal precursors to prevent neural development (reviewed in [ 69]).
TDP-43 is required autonomously in motor neurons and non-autonomously in glia to regulate various morphological and functional aspects of the neuromuscular junction.
Previous work has shown that MIG-13 is required autonomously in QR descendants to direct their anterior migration (Wang et al. 2013) and is repressed by MAB-5 in QL to allow posterior migration.
In order to analyze whether CTCF is required autonomously in the ecdysone-producing cells themselves to regulate Halloween gene expression we knocked down CTCF specifically in the PG using the UAS/Gal4 system.
Removal of Vret from the germline resulted in the eggshell patterning spindle phenotype but did not affect earlier aspects of germ cell or somatic differentiation, indicating that vret is required autonomously in the germline for oocyte polarity (Fig. 2A,B; see Table S2 in the supplementary material).
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Regarding melanophores and xanthophores, chimeric animals have shown that nac and pfe are required autonomously in the two cell types, respectively (Maderspacher and Nüsslein-Volhard, 2003; Parichy and Turner, 2003) (data not shown).
Consistent with an essential role of yki in CySCs, we found that yki was required autonomously for self-renewal in CySCs but not in GSCs (Fig 8A, E and F), the latter consistent with a prior report (Sun et al, 2008).
In addition, in the ventral forebrain, Rx function is required cell autonomously for the formation of the posterior pituitary.
We demonstrate that enz function is required cell autonomously by melanophores and that the enz locus is located on chromosome 7.
We have presented evidence that in mice Rx activity is required cell autonomously for the formation of the neuroretina, retina pigment epithelium and the distal optic stalk.
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