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In addition, a directed graph of the predicted interactions (a Cytoscape session file) is reported (Supplementary Material), in which each node denotes a gene and is labeled with the gene name, while each edge represents a significant predicted interaction; non-significant interactions, those where the absolute values of PARE scores are smaller than the threshold, are not plotted.

Terms with an adjusted p-value <= 0.05 were reported (Supplementary Table 1).

Potential mis-binnings were identified with CheckM13 where genome bin completeness and contamination are reported (Supplementary Table 4).

Only proteins identified with at least 95% confidence, or a Prot Score (protein confidence measure) of at least 1.3 were reported (Supplementary Table S1).

However, since no major differences were seen between the Reference Group and the full OBS population (Total OBS Subjects), results from both these groups are reported (Supplementary material).

No other disclosures were reported (Supplementary Data).

Results of additional secondary outcomes are reported (Supplementary Table 2).

More than 30 genes showing association with AR has been reported (Supplementary Table 1).

In CADASIL, at least 170 different mutations in 20 different exons have been reported (Supplementary Table 1).

The list of used antibodies is reported in Supplementary Information (Supplementary Table 1).

The species list for all genes is reported in supplementary table S2, Supplementary Material online.