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However, in certain types of cancer, telomere regulation of cell life span is rendered dysfunctional.
The p53 tumor suppressor gene is rendered dysfunctional in the majority of human cancers.
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At 73, I've been rendered dysfunctional by technology.
Its already troubled parliamentary democracy has been rendered dysfunctional in the aftermath of the 7 June election.
As strongly inferred in the downgrade of U.S. government debt by ratings agency Standard & Poor's, the democratic political system in the United States, and by extension in the U.K. and Eurozone, has been rendered dysfunctional due to general ineptitude, economic ignorance and ruinous internecine political conflict.
In most commercial chicken lines, Mx has been rendered dysfunctional by a single amino acid substitution [2].
We therefore wanted to determine if, in the liver environment, previously activated functional effector CD8+ T cells can be rendered dysfunctional and whether this process was dependent on specific antigen recognition within the liver.
Under normophysiological conditions, PHDs are the major inhibitors of HIF-1 activity during normoxia but are rendered dysfunctional during hypoxia [ 332] (Section 3.3.1 and Fig. 5).
Consequently, the expression plasmid may be rendered dysfunctional in replication, transcription or translation diminishing the occurrence of transformed cells that would be able to overexpress the targeted gene product.
In Northern Uganda, a recent study established that traditional social institutions that influence behaviour and regulate sex were rendered dysfunctional by conflict and displacement, thereby paving way for HRSB [ 5, 7].
It is rendering Congress dysfunctional and destroying respect for it among the American public.
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