Upon a through-coating damage, the mesoporous reservoir comes into contact with the aggressive electrolyte and benzotriazole molecules are able to be released and to inhibit corrosion of the bare metal exposed in the scratch.
Upon degradation of ϵ, the ζ toxin is released, allowing this enzyme to inhibit bacterial cell wall synthesis, which eventually triggers autolysis [ 34].
During self-injury, endorphins are released, which inhibit the individual from feeling much pain while making him/her feel happier.
Leukocytes containing β-endorphin, methionine-enkephalin, and dynorphin-A migrate to the site of injury and/or inflammation where the opioid peptides are released and help to inhibit pain [ 40- 42].
Although it is unclear whether these mechanisms occur in the CNS, it has been hypothesized that elastase is released from activated microglia that cleaves extracellular PGRN, whereas SLPI is thought to be released from astrocytes thereby inhibiting this cleavage event [ 26, 27].
Agar diffusion assays were used to investigate if the fibres contained sufficient ciprofloxacin and if the entrapped drug was released from the polymeric matrix to inhibit microbial growth.
As shown in Fig. 5a and Additional file 1: Figure S5, ESI†, the CI value of the MTX-PEG-CPT NRs was calculated as 0.35 (Fig. 5b), which indicated a highly synergistic effect of the MTX-PEG-CPT NRs' both drugs acting on HeLa cell (CPT was released and delivered to the nucleus for inhibiting DNA activity, whereas MTX to the cytoplasm for inhibiting DHFR enzyme activity).
The microtubule-detachment rate of this chimera that is ∼50-fold slower than kcat and ∼100-fold slower than mant-ADP release indicates that the motor head that just released ADP is unable to inhibit the ATP-turnover of the microtubule-bound head, as would be the case in fully processive kinesins.
Rat vascular smooth muscle cell (rSMC) proliferation was successfully inhibited when paclitaxel was released from pre-loaded PCUU coatings.
Previous studies demonstrated that addition of ≥350 pg/mL SDF-1 inhibited HIV replication in CD4+ cell culture [10], thus the amount of SDF-1 released into supernatants is sufficient to inhibit HIV replication.
