In some cases, symptoms were seen in people with B12 levels considerably above the levels that cause the best-known disease of B12 deficiency, anemia.The findings have prompted some experts to question whether blood levels of B12 now considered normal are really optimal.
"You would be able to use these kind of numbers to decide when is a good time to take a photograph, or maybe to choose the photograph that's really optimal in putting forward the best possible impression - and you might want to put forward different kinds of social impressions in different situations".
One can speculate whether the combinations of buffers and chromatography matrices used were really optimal since still details of only a limited number of IMAC phosphoprotein-enrichment applications were published.
"In a case like food packaging, especially condiment packaging," said Richard Denison, a senior scientist at Environmental Defense, an advocacy group in Washington, "using the least amount of materials is really the optimal approach".
A lawmaker might, without for one instant doubting that shoplifiting is a bad thing, question whether this is really the optimal use of federal law enforcement resources.
That's understandable: Tim Schafer is something of a cult figure in gaming, and is really an optimal rallying point for a Kickstarter project.
In this case, it can optimize any subsystem and path but without a general system, preliminary analysis it is not sure that the result of the design process is really the optimal one for the objectives.
Most countries will actually have laws which limit the time a dog can be left alone to between 4 and 6 hours, which is really the optimal time.
Linear flux analysis is simpler and requires less input information than a full kinetic analysis, and the question arises whether the consideration of non-linearities is really necessary for devising optimal strategies for yield improvements.
