We conclude that, during viral growth under either extended periods of selection or conditions that led to disease, viruses resistant to guanidine were readily selected in mice while viruses resistant to V-073 were not.
From these landscape models, compounds forming complex activity cliffs can be readily selected.
The compositions of municipal wastewaters vary; however, there are ranges of properties that enable filtration equipment to be readily selected and specified.
This technology allows high-affinity peptidic macrocycles containing modified backbones and unnatural side chains to be readily selected based on target binding.
With further refinement, the phage-derived analytical platforms for detecting and monitoring of numerous threat agents may be developed, since phage interface against any bacteria, virus or toxin may be readily selected from the landscape phage libraries.
Therefore, a large number of well-distributed polymorphic SNP markers can be readily selected for genotyping assays and used to develop smaller, 384-SNP assays that can be economically used to genotype the backcross progenies, allowing rapid selection of lines to advance during the backcrossing process.
Mutants resistant to these drugs are readily selected in cell culture [2], [3], [4], [5], suggesting that widespread use of these drugs has promoted the emergence of drug-resistant IAV strains in humans.
This is consistent with the results in mice, in which guanidine-resistant variants were readily selected.
Therefore, newly arising guanidine-resistant virus could be readily selected during guanidine treatment in mice infected with poliovirus.
Such systems may be more accessible since the engineering approach still comprises an element of trial and error and transcriptional output can be readily selected for.
