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We are all "Somewheres" to some extent, and the somewhere we belong to is rarely fixed and neatly bordered.
As a consequence the position of the assembled but un-extended mitotic spindle is rarely fixed within the cell.
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It is our understanding that unselected mutations are rarely fixed in such populations.
So, intuitively, the cost of breaking the physical relationship between long-range regulatory regions and their target genes may be so high that rearrangements are rarely fixed where such relationship is predominant (see also [ 31]).
This acquired resistance is associated with fitness costs so that resistance genes are rarely fixed in natural populations [ 41]; counterbalancing selection pressure decreases the frequency of resistance genes in the absence of inducer, such as a chemical pollutant.
More than half of the species accessory genes (1161) furthermore displayed homologues in only one or two strains implying relatively recent insertions that are rarely fixed in the population.
For example, HT DNA replication and repair genes (COG category L) are very rarely fixed, whereas carbohydrate metabolism genes (COG category G) are frequently fixed.
Shots are rarely fired.
In contrast, an increasing number of them settle in Morocco whether by primary choice or by default [ 22] as their journey is rarely planned from one fixed starting to another fixed end point and as failures along their journey might limit future options and drain resources [ 12, 21].
We know that there is rarely a quick fix in life.
Serial tumour sampling is rarely obtained in early-phase clinical trials, although fixed tissue from diagnosis is often available.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com