Mice that expressed the SmoA1 transgene and that were either wild-type or deficient in expression of Pten were prone to development of tumor in the developing mouse cerebellum.
It was reported that genetically-engineered RASAL2 knockout mice are prone to development of several sporadic tumor, including lung adenocarcinoma.
B. Regarding the choice of SD rats, EFSA notes that this "strain of rats chosen is known to be prone to development of tumours over their life This is neither taken into account nor discussed in the Séralini et al. (2012) publication".
Although advances in MI therapy have improved acute survival rates, such as percutaneous coronary intervention or coronary artery bypass graft, survivors are prone to development of chronic degenerative changes as a result of irreversible cardiomyocyte loss, extracellular matrix fibrosis, and pathological gene programming [3, 4].
Individuals carrying the Arctic mutation are known to be prone to development of AD early in life [19], possibly because of the formation of oligomers and protofibrils, considered to be more toxic aggregates of Aβ peptide than fibrils.
They suggested that individuals with p16 promoter methylation of normal tissue might be prone to development of cancer.
These observations indicate that SIRT1 LKO mice are prone to development of hepatic inflammation, which has been implicated in the progression of insulin resistance [ 9, 20].
In contrast, DBA/1 mice regained function of many finger joints without major bone remodelling after the inflammation went into remission (Fig. 2d,i), even though this strain is known to be prone to development of osteophytes [ 27].
However, the same group recently reported that caspase-14-deficient mice are prone to development of parakeratosis (persistent presence of nuclei in the cornified layer) in conditions triggering epidermal hyperproliferation.
The finding that a subset of the population is prone to the development of non-cardiogenic pulmonary oedema, as a result of exposure to hypoxia alone, is of relevance to our understanding of ARDS.
Skin is prone to the development of several diseases, varying from benign to malignant.
