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Furthermore, the latter approach is prone to detect non-tracer-related metabolites, significantly differing between the investigated sample types.
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One drawback of AP-MS, however, is that it is prone to detecting indirect interactions mixed with direct physical interactions.
Therefore, any network-based analysis is prone to detecting statistically significant properties due to an ill-posed null model (Artzy-Randrup et al., 2004).
Multiple factors may contribute to occurrence and development of breast cancer, and different samples may be prone to detect slightly inconsistent miRNA expression profiles.
Proteomic analyses are prone to detecting contaminants that are either highly abundant in target tissues or co-enriched during biochemical fractionation [22].
Specifically, (1) miRNAs are prone to detected homologous miRNAs with higher level of sequence similarity, (2) miRNAs are prone to cluster together with close physical distance, (3) some miRNAs are located on sense and antisense strands of specific genomic regions, and (4) miRNA locus can generate multiple isomiRs with various sequences and expression levels, and so forth.
Although only 88% of the samples derived from non-tumour areas of FP exhibiting turtles were CFPHV positive, this is also unsurprising - while in the active viraemic phase, herpesvirus DNA is prone to be detected throughout the body, it is likely that in chronic infections viral activity may be confined to nervous tissue [ 5, 37] and tumour sites.
Moreover, the random biopsy method is prone to low sensitivity in detecting clinically significant tumors [ 9– 12].
Although the evaluation of erectile function based on patient-reported data is prone to reporting bias, we could detect only a small effect of postoperative radiotherapy on erectile function.
While many editors and others have defended the system, they acknowledge that it is unlikely to detect fraud and is prone to abuse.
Although this achieves a good coverage of nodes, its simplistic design consumes non-negligible power, engenders network contention/interferences, and is prone to packet collisions that cannot be detected by the sender [11].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com