The number of participants with arsenic levels greater than the current MCL was prohibitively small to examine gene-environment interaction at arsenic concentrations greater than 10 μg/L.
In addition, it is likely that the number of respondents with experience with specific treatment combinations would be prohibitively small for a valid analysis.
Future prospective, randomized studies could possibly evaluate the efficacy of different durations of therapy; however, the power needed for such a study may be prohibitively small to detect a difference given the positive results reported here with 6 weeks of treatment.
For Goldwyn, the trick lies in selling to a pair of high-brow audiences — that for fine art, and that for new music — that are heavily embedded in a pair of cities, New York and Los Angeles, where conventional movie advertising is prohibitively expensive for small movies.
However, the number of terms in Equation 22 and, consequently, the number of channels that need to be estimated is ((2m_{max })^{n_{max }}), which is prohibitively large even for small values of m max and n max.
A $200,000 ticket is prohibitively expensive except for a small slice of the wealthy, but compared with the millions of dollars that government agencies like NASA typically spend to get experiments into space, "it's revolutionary," said S. Alan Stern, an associate vice president of the Southwest Research Institute's space sciences and engineering division in Boulder, Colo.
Unfortunately, the chemical synthesis of small RNAs is prohibitively expensive for numerous laboratories and experimental situations.
It's entirely possible that, in the future, we could see chemical engineering technology which is prohibitively expensive today filter down to laboratories and small commercial enterprises.
Even the iPhone SE, a lower-cost, smaller, and more limited version of the device, is prohibitively expensive for a lot of people in those countries.
