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"The panel is profoundly concerned that Dr Wakefield repeatedly breached fundamental principles of research medicine," the GMC said.
Mara Hvistendahl, a writer at Science magazine, is profoundly concerned, both about the fact that abortion was treated so casually, and the reason.
But understand this, too: At the core she is not a calculating crook but a smart, hard-working woman who is profoundly concerned with getting things done for those left behind.
It displays a consciousness that there is a constituency in the country, influential above its numbers, which is profoundly concerned by the effect of government policies on civil liberties, especially since David Blunkett's tenure at the Home Office.
The UN high commissioner for refugees has said it is "profoundly concerned" by Australia's plan to ban for life any asylum seeker who has attempted to reach the country by sea.
Like other Republicans the Guardian spoke with, LaMalfa, who is profoundly concerned for his constituents affected by the disaster, linked it less to anthropogenic conditions in the atmosphere than to forest-management policies by federal and state authorities, and specifically to efforts to limit logging.
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"It is profoundly concerning whether through overzealousness or incompetence, the local authority appears to be harassing tenants to give up their homes before legislation has even been passed in parliament," said Karen Buck, an MP in neighbouring Westminster who has campaigned against benefit cuts.
These assurances factored into my decision to vote against the Amash amendment to the Defense Appropriations Act, so this new report is profoundly concerning to me.
"[The fact that] it appears that there were tens of thousands -- if not hundreds of thousands -- of Americans who had their right to vote denied or compromised by having to wait in line five, six, seven hours is profoundly concerning and upsetting to me," Coons told reporters on Capitol Hill on Thursday morning.
And because they are profoundly concerned with also identifying the ways in which there are commonalities.
Everybody from BT to the Daily Mail group, along with individual citizens, should be profoundly concerned.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com