In regions where the scale of heterogeneity is smaller than the traditional 3 5 km averaging length, it has been problematic to relate measured flux signals to an individual land use.
It was clear to us that it may be problematic to relate extracellular properties recorded from primates to intracellular properties recorded in rats.
Immediately this is problematic to me.
Between-city comparisons are subject to potential confounding because covariates may be highly correlated with air pollution, whereas time-series studies are problematic to interpret because they relate short-term changes in air pollution that are driven primarily by meteorology to outcomes.
Older people with chronic physical illnesses and depression may be difficult to recruit because motivation may be problematic, as related to their mood difficulties.
The use of ADC values across MR systems is problematic because of differences related to magnet strength, vendor system and selection of differing b values [57].
However as long term administration of 6TG is problematic due to dose related toxicities, such as veno- occlusive disease, this study will assess the activity of 6-mercaptopurine (6MP), which is converted to the same active moiety, 6-thioguanine nucleotide, prior to incorporation into DNA.
We would ideally like to assess the ability of these aligners to find homologous relationships as well as geometric similarities for a large number of proteins but this is problematic since for distantly related proteins we rarely know how individual positions are related.
In addition, the small number of Asian American HCC patients with HCV is problematic, and the related results discussed above should be interpreted with caution.
The statistical tests are problematic because related individuals are not independent of each other, but there was no clear tendency for any specific locus to show departures from the expected Hardy-Weinberg frequencies.
However, measurement, particularly in post-menopausal women, is problematic because of assay variation related to low hormone levels and other unknown causes of variation in hormone levels over time [ 69].
