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Furthermore, it is problematic to differentiate the particle from the background fluorescence.
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A significant source of false-positives for this method comes from the fact that dual out-edges can be created by genome structure that is not just a SNP- any pair of k-mers that differ by a single end nucleotide causes the key bifurcation thus repeats, inversions and other low-complexity genome sequence can be problematic to differentiate from the desired SNPs.
It is tough to differentiate legitimate good links from bad.
Thus it is problematic to analyze allelic SNPs in B. napus as it is difficult to differentiate SNPs from the much more abundant inter-homoeolog polymorphisms (IHPs).
It was problematic to say the least.
Differentiating cerebral malaria (CM) from other causes of serious illness in African children is problematic, owing to the non-specific nature of the clinical presentation and the high prevalence of incidental parasitaemia.
However, the establishment of separate review processes for research and other types of evidence-generating initiatives is problematic because it requires one to differentiate between research and these other non-research initiatives.
It is important to differentiate between political and social differences.
With the exception of tyrosine, using titration to differentiate between hydrophobic amino acids is problematic.
That, to me, is problematic".
"Advertising healthier foods to children is problematic.
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