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While it is problematic to devise an experimental system suitable to monitor the dynamics of Ca2+ on a protein, one can use molecular dynamics to simulate the process and gain insights on the mechanism of the process.
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Immediately this is problematic to me.
The implications for ExxonMobil are problematic, to say the least.
It was problematic to say the least.
The silence is problematic and needs to be undone".
It was problematic enough to want to move.
That, to me, is problematic".
"Advertising healthier foods to children is problematic.
Therefore, it may be beneficial to devise an automatic detection system to help clinicians identify problematic images.
To Pakistan, that is problematic.
But, still, persuading them to come forward is problematic.
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