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p27Kip1 is a key cell-cycle regulator whose level is primarily regulated by the ubiquitin proteasome degradation pathway.
Since telomerase activity is primarily regulated through hTERT expression, understanding of hTERT regulation in normal cells is crucial for the understanding of carcinogenesis.
SREBF2 (SREBP2) is a major regulator of cholesterol biosynthesis and it is primarily regulated post-transcription by membrane traffic and proteolysis [34].
Taken together, these data provide evidence that Wnt11 expression is primarily regulated by VHL, HIF-1α and ARNT.
Nrf2 is primarily regulated by Keap1, a substrate adaptor for a Cul3-containing E3 ubiquitin ligase.
Although the securities industry is primarily regulated by specific rules, it is also governed by general principles.
Unlike tobacco, where the marketing is overseen by the FDA, alcohol advertising in the U.S. is primarily regulated by the alcohol companies themselves.
SREBP expression is primarily regulated by cellular cholesterol [36].
HIF-1α is primarily regulated at the post-translational level, with protein stability dependent upon pO2.
miRNA biogenesis is primarily regulated at the level of gene transcription [50].
In skeletal muscle cells, glucose utilization is primarily regulated by glucose uptake.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com