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VEGF, VEGF-B, and PlGF can bind and activate VEGFR-1, whereas VEGFR-2 is primarily activated by VEGF, and VEGFR-3 activation is only triggered by VEGF-C and VEGF-D [ 24].
Although JNK/SMAD signaling is primarily activated by resistance exercise, a subset of individuals displays activation of JNK/SMAD signaling with endurance exercise (Figs. 3 & 7).
In healthy humans, this novel JNK/SMAD2 signaling axis is primarily activated by resistance exercise, but not significantly activated by endurance (cycling) exercise (Fig. 7).
Thus, we identify JNK-induced phosphorylation of SMAD2 in its linker region as a novel signaling axis in human skeletal muscle that is primarily activated by hypertrophic stimuli, such as resistance exercise.
This part of our brain is concerned with our survival and is primarily activated by adrenaline, it's where our flight or fight response originates.
A contentious question has been whether polyQ-induced pathogenesis is primarily activated in the cytoplasm or in the cell nucleus.
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Since systemic administration and iontophoretic application of CGRP receptor antagonists into the spinal trigeminal nucleus are well suited to decrease spinal trigeminal activity [49], we have concluded that CGRP is primarily activating trigeminovascular neurons at their synapses within the trigeminal nucleus [21, 37] (Fig. 2c).
L-type calcium channels are primarily activated by depolarizing membrane potentials, raising important questions on how these channels may be regulated in non-excitable cells.
N-alkylnitrosamines with relatively short alkyl chains such as NDMA and NMEA were primarily activated by CYP2E1 as judged by mutagen-producing capacity.
In contrast to Q1/E1, Q1/E3 currents were primarily activated by PBA though a small amount of recovery from inhibition was observed as a rapid increase in current when the reagent was washed out.
MMP-2 is thought to be primarily activated by the membrane type 1 matrix metalloproteinase (MT1-MMP) and tissue inhibitors of metalloproteinases (TIMPs), but has also been shown to be activated in the absence of MT1-MMP, suggesting the presence of alternative modes of activation such as auto-activation [18].
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