Rather it defines a suite of pressure scenarios that accommodate uncertainty in these aspects, and seeks to identify indicators that are predicted to respond in a consistent fashion across these scenarios.
The resulting calculation showed that the time t, when the maximum number of neurons, that were born after the DG network was fully formed, contribute to spatial information processing, is at day 217, where 2057 of the adult-born neurons in the sample region are predicted to respond to spatial exploration (Fig. 5D).
Based on MHC binding affinity algorithms, mice expressing H-2b were predicted to respond poorly to α-Syn epitopes; yet 21 days after chronic MPTP-intoxication, B6 mice that express the H-2b haplotype yielded significant antibody responses to N-α-Syn.
Similarly, tumours with AKT1 mutation would not be predicted to respond to PI3K inhibitors.
In addition to these genetic candidates, our NEO analysis identified over 100 genes in the module that are predicted to respond to Cd44.
Consequently, if a patient's bladder tumour RT response could be predicted in advance, RT could be promoted in patients with tumours that are predicted to respond.
FcRL5 has been recently shown to bind to Fc of Ig (Wilson et al., 2012) and would be predicted to respond to environmental changes in the levels of immune complexes.
16 Patients exhibiting primary non-responsiveness to TNF inhibitors are likely to have non-TNF-α-mediated disease and consequently would be predicted to respond better to subsequent therapy with an alternative mode of action.
A common disease in this setting that is easily confused with leptospirosis is scrub typhus; both diseases would be predicted to respond to doxycycline, an antimicrobial drug often prescribed for undifferentiated fever.
It was interesting that 107 genes had abscisic acid response elements in their promoters, 138 gene promoters had auxin response cis-elements, 141 genes were predicted to respond to gibberellin, and 192 gene promoters had jasmonic acid responsive elements.
