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MD ranks fifth among leading causes of global disease burden including developing countries, and by year 2030 it is predicted to represent one of the three leading causes of burden of disease worldwide [1], [2].
The novel DNA sequence variation g.56167A>G which is predicted to represent a synonymous p.S434S variation was found in this study in a patient with bilateral, progressive, mild to moderate sensorineural hearing loss who is also homozygous for the controversial p.V37I variation in GJB2 [25].
It should be noted that our proteomics study identified approximately 500 muscle proteins, which is predicted to represent only a fraction of the total muscle proteome.
The group with high sputum eosinophil count and low red hue in vivo is predicted to represent those subjects with the greatest impairment in MDM efferocytosis of eosinophils, which was confirmed in vitro.
The 40 most abundant sequences detected by assembly of the survey data, the number of reads encoding each, and the percentage of the genome that each is predicted to represent, are summarized in Additional File 1.
Based on this frequency of "false" or duplicate clones, the entire microarray is predicted to represent 4301 unique P. marneffei genes, which is 42% of the predicted genes in the genome.
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The wild-type alleles were predicted to represent 94.8% of haplotypes (Fig. 1B).
Thus, functional M5-DLO flippases are predicted to represent ∼1% (w/w) of the proteins in TE.
Within these graph-clusters, we identified 554 components that are predicted to represent highly divergent alleles of the same gene that can then be merged, 1,293 components that are predicted to represent alternative splicing events, and 158 components (pairs of duplicated contigs) that are predicted to represent duplicated genes.
When these BESs were subjected to sequence homology searches, it was found that 641 (11.6%) were predicted to represent protein-encoding regions, whereas 1,272 (23.0%) contained repetitive DNA.
The 64 SNPs that were predicted to represent differences between genes (paralogs or members of gene families) were removed prior to analysis of segregation patterns.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com