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Compound 15l is potent against gatekeeper mutant (IC50 = 252 nM) of RET as well as against wild-type RET (IC50 = 44 nM).
Telavancin, like oritavancin, is potent against both penicillin-susceptible and -resistant strains of S. pneumoniae.
Moreover, Moss et al. described that the metalloproteinase inhibitor marimastat is potent against ADAM9 [ 48].
Lys-CoA is potent against p300, with a Ki of 19 nM, and is between 50- and 400-fold tighter binding than CoASH alone.
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Several herbs, especially St.-John's-wort and yarrow, are potent against fairies, and hawthorn trees, foxglove, and groundsel are so dear to them that abuse of these plants may bring retribution.
Benchmark compounds 30, 35, and 36 were found to be potent against the enzyme.
Most of the compounds were found to be potent against both ChEs and MAO-B.
The results showed that NO-donating acridones are potent against both the sensitive and resistant cells.
Interestingly, among all the extracts tested, only EA extract was potent against Candida tropicalis with a total activity of 41.4 ml g−1.
Cbf-14 (RLLRKFFRKLKKSV), a designed peptide derived from cathelicidin family AMP, has proven to be potent against drug-resistant bacteria.
In addition, compounds 16 and 21 were potent against non-replicating Mycobacterium tuberculosis and compound 21 was bactericidal.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com