The seven or eight nucleotides at the 5' end of a miRNA that has been postulated to serve as the primary determinant of target specificity.
A variety of cytokines, chemokines and defensins have been postulated to serve as important markers of response for diagnostic purposes [8], [10], [11].
Rather, it seems to be located at the surfaces of small vesicles within the cell that have been postulated to serve as storage for manganese.
Hence, TSPY has been postulated to serve a physiological function(s) in stem germ cell proliferation and in directing the spermatogonial cells to enter male meiosis [ 4, 9].
In vivo, fibroblasts in tumor tissue have been postulated to serve as a source of pro-oncogenic cytokines, including IL-6 [ 31].
Translocation of CaMKII to the NMDA receptor requires active subunits and has been postulated to serve as a molecular memory (Bayer et al., 2001; Jiao et al., 2011; Lemieux et al., 2012; Neant-Fery et al., 2012).
Following a slightly different tack, some groups are also investigating biomarker and genetic characteristics of DTCs from bone marrow [ 14- 16], which are postulated to serve as a reservoir for active and dormant tumor cells [ 12, 17].
The appendix, particularly its microbial-rich biofilm, has long been postulated to serve as a repository for repopulating the distal gut following an insult such as diarrheal disease or antibiotic exposure (Randal Bollinger et al., 2007).
Also, HMW complexes containing MMP9 have been postulated to serve as a reservoir of active MMP9 protecting it from the rapid degradation when present in biological fluids [ 13, 15].
These and other mutant murine strains had been postulated to serve as animal models of HPS (Hermansky Pudlak syndrome), which is a rare genetic disorder characterized by defective biogenesis of melanosomes, platelet dense granules and other lysosome-related organelles (Swank et al., 1998).
