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Testosterone regulation of the neonatal SDN is postulated to involve local aromatisation of androgens to oestrogens [ 21, 32, 33].
The uptake of FDG by cancer cells is postulated to involve the same mechanism as in inflammatory cells.
The development of hormone resistance in ER+ but endocrine-refractory metastatic disease is postulated to involve signal transduction pathways, including mammalian target of rapamycin (mTOR).
The cessation of DNA synthesis and end-bud regression caused by exogenous TGF-β-induced ECM is postulated to involve the concomitant induction of periepithelial ECM around end-buds [ 39].
The mechanism of injury is postulated to involve cell mediated immunity [ 9, 10] and the syndrome is often associated with extrarenal manifestations of hypersensitivity, such as rash, fever and eosinophilia.
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While the detailed mechanism by which UA contributes to intracellular signaling networks is unknown, it has been postulated to involve intracellular redox dependent mechanisms.
Loss of ΔΨm has been postulated to involve opening of a large permeability transition pore (PTP).
Changes associated with tissue ageing and degeneration have been postulated to involve cellular senescence [ 41- 43].
Species differences are postulated to involve kinetics of several biochemical and physiological events acting in concert or competition.
Mannose (Man) is a Glc analogue that inhibits seed germination and early seedling development at millimolar concentrations via a mechanism that has been postulated to involve hexokinase [ 35].
Second, the early stages of DPN are postulated to involve small fibers first; in IGT patients, this may, but not always, manifest as painful neuropathy (10).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com