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One mechanism that may contribute to limited efficacy of antiplatelet therapy in such patients is persistently increased platelet reactivity.
Our observation that TRIM62 is persistently increased in muscles of critically ill patients at high risk of developing ICUAW and in all atrophy mouse models strengthens this hypothesis.
Figure 4c shows that mean values of fEPSP slope were persistently increased in slices prepared from the DH, IH and VH.
The 3-MA-sensitive degradation was persistently increased after glutamine removal.
Risk also was persistently increased regardless of frequency of binge drinking each month.
We demonstrate that TGF-β pathway activation was persistently increased in the SVZ niches of irradiated or aged mice.
A few days later the liver enzyme activities were persistently increased and the dog was coagulopathic indicating substantial liver dysfunction.
Note that in the presence of calyculin, the steady state mEPSC frequency was persistently increased (see Figure1 source data 1D ).
In the female midbrain, IL-6 was increased only at PND55, whereas TNFα and IL-1β were persistently increased across both time points.
By contrast, the activation of the angiogenic VEGF/KDR pathway was persistently increased in RA, as indeed was microvessel density and the expression of PD-ECGF, irrespective of the extent of HIF-α expression, indicating a cytokine-dependent angiogenesis.
In addition, the expression of purinergic receptor P2X, ligand-gated ion channel 4 (P2RX4), which has been shown to regulate the inflammasome activation after spinal cord injury [ 105] was persistently increased in our injury model.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com