In melanoma, this pathway is particularly active because of a commonly found activating mutation in B-Raf V600E (Davies et al., 2002) that bypasses Ras and the negative feedback that normally restrains MEK/Erk activity (Logue and Morrison, 2012).
The Nrf2 pathway is particularly active in astrocytes, compared with neurons (although activation of Nrf2 in neurons is possible [ 110]), and activation of astrocytic Nrf2 is sufficient to confer neuroprotection on nearby neurons via a mechanism proposed to involve the release of glutathione [ 103, 105, 111].
Other drugs such as alkylating agents (e.g. treosulfan) also have activity and we have shown that the combination of treosulfan+gemcitabine is particularly active (Cree, 2003; Sharma et al, 2003).
It is particularly active in China.
But he is particularly active now.
He is particularly active at the Anteon International Corporation.
The Obama administration is particularly active in this regard.
Engagement, and Google is particularly active in engaging researchers and activists, is vital.
The mice were crossed with a strain of mice in which the sirtuin-making gene is particularly active.
These days, the waste-to-energy debate is particularly active in Europe, where government incentives and subsidies have encouraged the construction of incinerators.
Mr. Weill, he said, is particularly active in efforts to improve health care in Africa, which Mr. Weill said he planned to visit again next year.
