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In addition, Lys117 and Lys147 were just the two residues on the interface binding pocket of HRas with Ras-specific GTPase activating proteins (RasGAPs, or GAPs), and GAPs, which supply additional catalytic residues ('arginine finger') such that a water molecule is optimally positioned for a nucleophilic attack on the gamma phosphate of GTP, hydrolyze a bound GTP molecule into GDP.
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If the nicotinamide ring of the coenzyme NAD(P H were in the same position as that of the nicotinic acid ligand, its C4 atom would be optimally positioned for direct hydride transfer to flavin N5.
In the active conformation, all key catalytic residues are optimally positioned for catalysis, and two conserved networks of hydrophobic "spines" are aligned.
Indeed, in the MCC crystal structure, a Mad3 KEN box is optimally positioned by Mad2 to obscure the recognition sites for the KEN box degron on Cdc20, providing support for the pseudosubstrate model (Chao et al. 2012).
The flowering of the Bay Area cabaret scene ultimately suggests an enduring hunger for the close-knit exchanges with performers that the format is optimally positioned to provide.
One of these water molecules (WAT1) is optimally positioned to be the nucleophile.
Thus, Spire1C is optimally positioned to serve as a molecular hub that links mitochondria to actin and the ER for regulation of mitochondrial division.
When the woman is optimally positioned, table and patient are moved into the magnet, so that her breasts are in the centre of the tube: the magnetic field is most homogeneous at that position allowing for optimal image quality.
They are optimally positioned and not collocated.
Leaving this rod to the end allows the Sheffield clamp to be optimally positioned first (Fig. 14 D).
We next selected SNPs directly from online databases that differentiated East Asians from the other two groups and were optimally positioned in the genome [1].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com