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The other drug, eflornithine, is less toxic, though it is only efficacious for the gambiense subspecies and requires large amounts of drug which must be delivered by infusion over 14 days.
For example, if a therapeutic intervention showed promise in one study but not another, a potential reason could be that the groups had significantly different mean peak VO2's and the therapy is only efficacious for those with adequate aerobic reserve.
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The survival of MRSA-infected nematodes exposed to UE-02-4, UE-11 and UC-10 was less than 40% indicating that these three hits were only efficacious for MSSA but not MRSA infections.
This is not surprising given the poor efficacy of SP. As a monotherapy, ART is usually taken for 7 days; a 3-day ACT course is only efficacious when the second drug retains adequate efficacy.
Among patients on pegylated-interferon and ribavirin only, treatment is only efficacious in approximately 55% of treatment-naïve patients [ 7].
Pemetrexed was only efficacious in a non-squamous population and erlotinib was efficacious in both the intent-to-treat and stable disease populations.
Earlier research has shown that interventions targeting cognitive factors derived from Ehlers and Clark's theoretical model are not only efficacious for the treatment of chronic PTSD [ 54], but are also highly effective as an early intervention following trauma [ 55].
Cisplatin-based chemotherapy is used for the treatment of advanced stage cases, but is only moderately efficacious.
However, it is only suitable at sub-maximum efficacious levels.
Commercial vaccines are only partially efficacious under field conditions.
The xanthine 7-riboside DBXRM, a full agonist, was only partially efficacious in β-arrestin translocation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com