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This is an important limitation since in clinical practice the dose of a drug is often titrated and flexible dose studies tend to report fewer adverse events.
Meta-analysis should be sensitive to this, and to the clinical reality, that dose is often titrated to effect [ 25].
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In the ICU SpO2 is often used to titrate the FiO2 (see later) but has also been recently suggested to play a role in the definition of ARDS.
The right ventricular/left ventricular (RV/LV) area ratio is often used to titrate airway pressure during mechanical ventilation [ 1].
Indeed, it has been pointed out that there may be unintended harmful consequences in studies that use fixed treatment protocols for therapies that are more often titrated in day-to-day practice [ 20].
Also, a wide range of doses are reported, although it is often suggested that the medication be titrated to a maximum dose of 2,000 mg/day, divided twice daily, based on effectiveness and tolerance of side effects (27, 28).
For example, the educator is often in the position where she/he would like to advocate for the patient and contact the physician, or follow a clinical protocol to titrate medications.
Telemonitoring is often used to monitor patients at home and guide patients to take action in case of deterioration, but it also can be used to up-titrate medication according to guidelines at distance [ 23].
In addition, patients and physicians are often reluctant to titrate insulin because of the fear of hypoglycemia.
This suggested that quetiapine XR might be more beneficial to patients with an acute schizophrenic episode since the high loading dose might have faster efficacy but have a lower incidence of adverse events such as postural hypotension, somnolence and dizziness [ 31] which quetiapine IR was often recommended to be slowly titrated up to avoid the occurrence [ 27, 28, 47].
The sample to be titrated is predissolved in 15 mL of KCl/water-saturated octanol, usually with sonication, and often with slight warming.
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