Because lipids are now known to play an important role in cell signaling and regulation of homeostasis, and are often perturbed in malignancies, we undertook a comprehensive lipidomic survey of plasma from AML patients at time of diagnosis and also healthy blood donors.
Especially, the ecological systems in practical world are often perturbed by various types of environmental noises.
In practice, both y and A are often perturbed in model (1).
Signalling pathways also are often perturbed.
Protein-protein interactions (PPIs) are central to the proper functioning of the most basic molecular mechanisms underlying cellular life, and are often perturbed in disease states.
Besides the finding that imprinted small RNAs play specific roles in development, behavior and metabolic processes, recent studies show that imprinted microRNAs are often perturbed in cancer.
Several mechanisms are in place in normal cells that protect against chromosome and nucleotide damage by preventing DNA replication until damage is repaired; however, genes controlling these critical checkpoints (e.g. p53) are often perturbed in cancer cells [ 16].
Most notable, however, advances in large-scale protein-interaction mapping have led to a significant expansion in our understanding of both the composition of protein complexes and their arrangement within broader cellular PPI networks that are often perturbed under disease states.
I don't think McShane is much perturbed.
