However, several drug makers have preferred the use of a 3-category scale, namely "Unlikely," "Possible" and "Probable" (Table 3 ), for the following reasons: (1) Due to various practical limitations, cases documented during drug development are often not evaluated as completely as the DILIN cases, and are often missing some data.
Allodynia is often not routinely evaluated during a headache history even though there may be potential therapeutic implications.
It is often not feasible to evaluate a system based on surgical outcome or the impact of the system on the patient, but it is possible to evaluate these systems indirectly in phantoms and/or controlled environments [ 7].
61 Unlike en bloc retrieval, piecemeal removal results in the retrieval of poorer quality histological samples and it is often not possible to evaluate the completeness of resection, depth of invasion, lateral resection margins and other prognostic features.
Such an approach is often not possible or unsuitable to evaluate the benefit-risk balance in special populations (e.g., children, ethnic groups, rare diseases).
Most trials evaluating renal dysfunction are binary, in that ARF is present or absent; AKI is often not addressed.
Responsibility is often not internalized.
Decision support systems are often not empirically evaluated, especially the underlying modelling components.
As an example, computational benchmark-type studies that are often not rigorously evaluated and not reproducible represent a recurrent type of publication in the chemoinformatics literature.
New and expensive drugs also have a major impact on ICU costs, but they are often not adequately evaluated for cost-effectiveness [ 52, 53].
