This time interval is often clinically impracticable, as some patients require immediate treatment and some do not want to wait.
Direct measurement of biochemical parameters in vivo is often difficult and sometimes impracticable, while fitting them under data-poor conditions may result in biologically implausible values.
This made MSME sequences impracticable for larger study populations as scanning time in μMRI is often limited.
Second, the representativeness of task performance samples analysed by such tools is often dubious, partly because in many jobs it is common for workers to perform a variety of tasks for variable amounts of time, which makes it impracticable for observers to take adequate account of all physical exposures and their durations [ 29, 53, 56].
Another problem in such a trial is that experimental blinding of the assessor is impracticable because the cupping marks are often visible and may persist for several days.
It is impracticable to upgrade the 18,900 Australian passive crossings as such crossings are often located in remote areas, where power is lacking and with low road and rail traffic.
Numerical techniques are often the unique viable option for computing these designs since to tackle analytically the problem results impracticable in most of cases.
While doing so might at first seem impracticable, reductions in costs of the technical methods (Lemmon et al. 2012; Rocha et al. 2013), and routine surveillance of areas for incoming species (e.g. Bourlat et al. 2013), which are often the same sources for outgoing ones (Lee and Chown 2009), mean that the data may become increasingly available for species detection.
To reliably identify the leading endogenous substrates of a transporter this approach requires sequential testing of large numbers of potential substrates in separate uptake experiments, which is at best inefficient but often impracticable (e.g. due to limited availability of authentic standards).
