Low-dose proton pump inhibitors (PPIs) are often administrated as maintenance therapy for gastroesophageal reflux disease (GERD) and on-demand PPI therapy is a viable option for long-term management of GERD.
During the implantation of blood-contacting materials or devices in clinic, heparin was often administrated with the aim of anticoagulation.
For instance, in hospitals, antibiotics are often administrated both before and after a surgical operation to reduce the risk of complications caused by bacterial infections.
It is often difficult to substitute with alternative regimes because of overlapping toxicities, previous drug resistance, or difficulties in administrating the drug.
Once bacterial vaccines are administrated into the animal host, they are often internalized by phagocytes via different entry mechanism.
Thus, endotoxinic shock has often been used as a surrogate of septic shock, and experimental immunomodulatory drugs have most often been administrated prior to or concomitant to the infectious insult [13].
Thus, endotoxinic shock has often been used as a surrogate of septic shock, and experimental immunomodulatory drugs have most often been administrated prior to or concomitant to the infectious insult [ 13].
Another possibility is thrombolysis administrated locally using interventional therapy [5 7].
