The use of fixed, as opposed to estimated, category intercepts was not anticipated to be of substantial consequence to the proposed question of interest, which concerned the direction and magnitude of the between- country correlations observed.
The process continues until the last IMF or the residue is less than a predetermined value of substantial consequence, or when the residue becomes a monotonic function from which no more IMF can be extracted.
Anybody who was not strong enough to cause substantial material damage was of no consequence.
There would be substantial consequences in financial markets from such a default on US government debt.
The secular decline in breast cancer mortality caused by progress in treatment is substantial, and one consequence of further improvements in treatment is that increasingly more women will need to be invited to mammography screening to prevent one death from breast cancer.
Another cited study associating antidepressant use with an increased risk of ADHD actually found no increase in autism risk when maternal mental illness was taken into account and concluded that the increased ADHD risk was "modest in absolute terms... and must be balanced against the substantial consequences of untreated maternal depression".
The observed gene expression stability in both the sciatic nerve endoneurium and the DRG early after the onset of diabetes suggest that the early (reversible) phase of DPN is not a consequence of substantial transcriptional changes.
The spatial and temporal extent of disturbance is substantial, and potential consequences are discussed.
22 The burden of vision loss is substantial and its consequences are numerous, from functional to social and psychological, and it can lead to depression.
