The phrase "is of significant" is not correct in written English.
You could use the phrase "is significantly" instead. For example: This increase in cost is significantly higher than expected.
"There is some debris outside the church that is of significant concern".
It is of significant historic interest and will, somehow, be saved.
Nursing competence is of significant importance for patient care.
Thus, understanding its molecular architecture is of significant interest.
Detection of pollutants is of significant importance for environmental protection.
The duration of the methane flux is of significant importance.
This finding is of significant technical and economic importance.
It is of significant utility for aptamer-mediated targeted delivery.
Therefore, tolerance allocation is of significant importance for successful assembly.
Thus, the fluctuating combination of retained and inventive elements is of significant interest.
Early identification of individuals at risk for chronic diseases is of significant clinical value.
