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Certainly, PI control of study design would seem to be of questionable applicability in cases where the design of the study is determined in advance by explicit regulatory agency direction.
The first method is of questionable value.
"But it is of questionable good safety...
This makes studies of older designs sometimes of questionable applicability to those currently being sold.
However, health care providers are often faced with a paucity of evidence for specific patient groups such as children and youth, and thus must rely on evidence of questionable applicability as the basis for their health care decisions.
However, your articles were of questionable taste.
CTCs are of questionable utility in non-metastatic prostate cancer.
Many of these are of questionable quality.
Most research on IBS has been performed on referred patients with IBS with questionable applicability in a general practice setting.
Commonly identified flaws in reliability studies are the exclusive use of healthy individuals, questionable applicability in clinical practice, low sample size, the absence of a protocol and the use of inadequate statistics [ 18].
Commonly identified flaws in these reliability studies were low sample size, unclear selection criteria, the use of only healthy individuals, use of inadequate reliability statistics, the absence of a protocol, and questionable applicability in clinical practice.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com