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We increased the ventilator rate over the course of the study to attenuate the development of the metabolic acidosis that is observed in this model [20].
Both ACTH and α-MSH could reach the inflamed mesentery as part of the plasma protein externalization response that is observed in this model; as expected, this response was optimal at earlier time points compared with the cellular response (45 min vs. ≥60 min).
For the analysis of pathological significance of misfolded SOD1 KAP3 association in this PNG3 cell model system, we next asked whether association of KAP3 with misfolded SOD1 is observed in this model just as we saw in the SOD1 G93A -Tg mice.
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The author claims immune tolerance is responsible for the observed results rather then immune ignorance, since CTL responses were observed in this model.
No significant interactions were observed in this model.
Although some nuclear staining has been observed in this model, distinct cytoplasmic inclusion-like structures have been consistently identified by confocal and electron microscopy [19], [55], [56], [57].
However, contrarily to humans, no pre-retinal neovascularization and no ischemic area are observed in this model, even at late stages.
However, the age at which invasive tumors are observed in this model would correspond to early adulthood in humans and do not accurately reflect the more protracted developmental time-course of prostate cancer in humans.
Even though there exists no direct equivalent of human episodic memory in the small nematode C. elegans, several forms of associative behaviour and long-term memory have been observed in this model organism [8] [11].
Having shown that the mouse model was very sensitive to the dose of antigen used for vaccination, we next examined the protective efficacy of Ag85B-TB10.4/IC31® in the guinea pig TB model, and whether a dose dependency would also be observed in this model.
No in vivo adverse effect of LAB027 was observed in this model.
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