Late toxicity was not well evaluated and a long-term follow-up of the patients is important to assess the real incidence of long-term side effects of the chemoradiotherapy and the impact on quality of life.
However, factors that contribute to faecal COX-2 mRNA expression were not well evaluated.
However, the in vivo chemopreventive and anti-tumor immunomodulatory effects were not well evaluated.
Agronomic traits are not well evaluated in wild M. sativa because of its prostrate growth habit, so the dense map obtained in wild diploid M. sativa [ 8] can hardly be used for QTL detection of agronomic traits.
The review also highlighted it was difficult to accurately assess the potential public health impact in terms of effectiveness as some interventions were not well evaluated, evidenced by the large number of inconclusive reviews and reviews demonstrating no effect.
A few studies have demonstrated improved clinical outcomes following the introduction of evidence based protocols [ 26- 28], however, the relative benefits (both in patient outcomes and effective use of health resources) of alternative models of care are not well evaluated.
Because the effect of dexamethasone on lactate levels is not well understood, we evaluated the role of glucose as an intermediate in the relation between dexamethasone and postoperative lactate levels.
Although the exact role of Th17 cells in the pathogenesis of intestinal bowel diseases is not well understood, recent studies evaluating the role of Th1 and Th17 cells in the induction of experimental colitis in mice have shown a prevalence of Th17 cells over their Th1 counterpart in the inflamed gut [ 9].
The clinical importance of small screening-detected cancers is not well understood and we could not evaluate it in this study based on the first round of screening.
The relative contribution of these mechanisms in vivo and in different lymphoma subtypes is not well known and remains to be further evaluated.
