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However, this seems unlikely because such an effect is not recapitulated in our growth curves (Fig. 8C and 8D, Figure S5).
Since the characteristic DRBP76 isoform distribution in normal tissues is not recapitulated in transformed cells, this left us with performing analyses of the ∼90 kDa form characteristically associated with CNS malignancy or transformed cells.
Again, this is not recapitulated in the ChIP-qPCR.
Another significant limitation of the organoid culture is that the whole-animal phenotype is not recapitulated.
Therefore, articular cartilage maturation is partly a developmentally encoded process, and is not recapitulated fully in more mature animals through biomechanical conditioning alone.
This suggests that IBC cells present a highly specific profile of essential genes that is not recapitulated by other breast cancer subtypes.
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However, these observations are not recapitulated on application of transmural pressure (PTM) oscillations (that mimic tidal breathing and DIs) in isolated intact airways.
The allogeneic extracellular matrix derived hydrogels elicited significantly reduced total, human specific, and CD4+ T-helper cell infiltration in humanized mice compared to xenogeneic extracellular matrix hydrogels, which was not recapitulated in wild type mice.
The ropB mutation of strain 5628 was not recapitulated on passage in the mouse subcutaneous infection model.
In addition to the usual caveats of overexpression data, this result was not recapitulated by the same group when using a different plasmid system [22].
The enhanced sensitivity to low-dose STZ was not recapitulated in WT mice denuded of intestinal flora upon the long-term administration of broad-spectrum antibiotics.
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